Markus Branse has added a photo to the pool:
Dusk, Litchfield Park Road, Northern Territory, Australia
Markus Branse has added a photo to the pool:
Dusk, Litchfield Park Road, Northern Territory, Australia
NBC News reports on a 16-person clinical trial of "personalized messenger RNA vaccines" which use the immune system to fight cancer cells. "The goal is not to eliminate existing tumors, but instead to stamp out lingering, undetected cancer cells, and later any new cells that form before they can cause a recurrence."
Patients still have surgery to remove tumors. After that, the mRNA vaccines are personalized for each individual using genetic material taken from their unique tumor cells. In the clinical trial, after getting the vaccine, the patients also received chemotherapy, which is standard post-op treatment for operable pancreatic cancer... [The article notes that less than 13% of people diagnosed with pancreatic cancer live for more than five years, making it "one of the deadliest cancers."]
[E]xperts have long believed that people with pancreatic cancer could not generate an immune response against tumors. But after nine doses of the personalized vaccine, [clinical trial participant Donna] Gustafson is one of eight people in the 16-person Phase 1 trial who did just that, producing an army of immune cells called T cells that seek out and destroy tumor cells... [Dr. Vinod Balachandran, a vaccine center director who is leading the trial, said] it was unclear whether the immune response would last and lead to the patients living longer... New data collected during the trial's six-year follow-up period shows that it may. Those findings will be presented Monday at the American Association for Cancer Research's annual meeting in San Diego. Six years after treatment, Gustafson and six others who responded to the treatment are still alive...
More research is still needed. Genentech and BioNTech, the two drugmakers behind the vaccine, have already launched a larger Phase 2 clinical trial... Another team is working on an off-the-shelf vaccine that targets a protein called KRAS that is present in as many as 90% of pancreatic cancers. In a small, early trial, about 85% of the participants mounted an immune response to the protein.
Patients still have surgery to remove tumors. After that, the mRNA vaccines are personalized for each individual using genetic material taken from their unique tumor cells. In the clinical trial, after getting the vaccine, the patients also received chemotherapy, which is standard post-op treatment for operable pancreatic cancer... [The article notes that less than 13% of people diagnosed with pancreatic cancer live for more than five years, making it "one of the deadliest cancers."]
[E]xperts have long believed that people with pancreatic cancer could not generate an immune response against tumors. But after nine doses of the personalized vaccine, [clinical trial participant Donna] Gustafson is one of eight people in the 16-person Phase 1 trial who did just that, producing an army of immune cells called T cells that seek out and destroy tumor cells... [Dr. Vinod Balachandran, a vaccine center director who is leading the trial, said] it was unclear whether the immune response would last and lead to the patients living longer... New data collected during the trial's six-year follow-up period shows that it may. Those findings will be presented Monday at the American Association for Cancer Research's annual meeting in San Diego. Six years after treatment, Gustafson and six others who responded to the treatment are still alive...
More research is still needed. Genentech and BioNTech, the two drugmakers behind the vaccine, have already launched a larger Phase 2 clinical trial... Another team is working on an off-the-shelf vaccine that targets a protein called KRAS that is present in as many as 90% of pancreatic cancers. In a small, early trial, about 85% of the participants mounted an immune response to the protein.
Read more of this story at Slashdot.
"Motorola has filed a lawsuit in India against social media platforms and content creators," reports TechCrunch, "over posts it alleges are defamatory..."
The lawsuit, filed in a Bengaluru court and obtained by TechCrunch, names platforms such as X, YouTube, and Instagram along with dozens of content creators, and seeks takedown of the content as well as broader restraint on what it describes as false or defamatory material related to the company's devices. In its over 60-page filing, Motorola has sought a permanent injunction restraining the defendants from publishing or sharing what it describes as false or defamatory content about its products, including reviews, videos, comments, and boycott campaigns.
The complaint cites hundreds of posts across platforms, including videos alleging device issues and phones catching fire. But it is also targeting unfavorable product reviews and user commentary that the company alleges are false or defamatory. In a statement after publication, a Motorola spokesperson said it had initiated legal action "in the interest of public safety" against what it described as demonstrably false claims that its devices had exploded or caught fire.
One online creator told TechCrunch "they expect more such legal action in the future, as evolving rules around online content increase liability for creators and platforms — a trend reflected in recently proposed changes to India's IT rules aimed at tightening oversight of online content."
A Motorola spokesperson "said the company did not seek to suppress legitimate reviews or criticism and was reviewing the scope of the proceedings, adding that it apologized to creators affected inadvertently."
The lawsuit, filed in a Bengaluru court and obtained by TechCrunch, names platforms such as X, YouTube, and Instagram along with dozens of content creators, and seeks takedown of the content as well as broader restraint on what it describes as false or defamatory material related to the company's devices. In its over 60-page filing, Motorola has sought a permanent injunction restraining the defendants from publishing or sharing what it describes as false or defamatory content about its products, including reviews, videos, comments, and boycott campaigns.
The complaint cites hundreds of posts across platforms, including videos alleging device issues and phones catching fire. But it is also targeting unfavorable product reviews and user commentary that the company alleges are false or defamatory. In a statement after publication, a Motorola spokesperson said it had initiated legal action "in the interest of public safety" against what it described as demonstrably false claims that its devices had exploded or caught fire.
One online creator told TechCrunch "they expect more such legal action in the future, as evolving rules around online content increase liability for creators and platforms — a trend reflected in recently proposed changes to India's IT rules aimed at tightening oversight of online content."
A Motorola spokesperson "said the company did not seek to suppress legitimate reviews or criticism and was reviewing the scope of the proceedings, adding that it apologized to creators affected inadvertently."
Read more of this story at Slashdot.
Thomas Hawk posted a photo:
SOFIA (ANP/BLOOMBERG) - Voormalig president Rumen Radev, die zich verzet tegen sancties tegen Rusland en militaire steun aan Oekraïne, heeft de overwinning geclaimd in de Bulgaarse parlementsverkiezingen. Hij beloofde vernieuwing na jaren van politieke impasse en corruptie.
Bij de achtste algemene verkiezingen van het land sinds 2021 stevent Radevs partij, Progressief Bulgarije, af op een absolute meerderheid met 129 zetels in het 240 zetels tellende parlement, zo blijkt uit een prognose van peilingsbureau Alpha Research. Radev ligt op koers om 44 procent van de stemmen te behalen. Daarmee ligt hij 30 procentpunten voor op zijn naaste uitdager, voormalig premier Bojko Borissov, die zijn nederlaag heeft erkend.
"Progressief Bulgarije wint ondubbelzinnig", zei de 62-jarige Radev tegen verslaggevers in Sofia nadat de prognoses waren gepubliceerd. "Dit is een overwinning van hoop op wantrouwen. Dit is een overwinning van vrijheid op angst. En ten slotte is dit een overwinning, als ik dat zo mag zeggen, van de moraal."
Hongarije
Radev trad in januari af als staatshoofd om deel te nemen aan de verkiezingen, nadat een golf van demonstraties een coalitie onder leiding van Borissovs partij GERB ten val had gebracht. Met de belofte om de strijd aan te binden met wat hij een corrupte elite noemde, vergaarde hij steun vanuit het gehele politieke spectrum. Hij deed dit met beloften de rechterlijke macht te hervormen, de inkomens van kiezers uit de arbeidersklasse te verhogen en bruggen te slaan naar het Kremlin.
Met de nederlaag van Viktor Orbán in Hongarije, een week geleden, heeft het Kremlin net zijn belangrijkste bondgenoot binnen de EU verloren. Het is onduidelijk of Radev zal proberen de nadruk van het EU-beleid te verleggen richting Moskou. Hij heeft ook verklaard dat hij de EU en de NAVO wil versterken.
HANNOVER (ANP/DPA) - De Braziliaanse president Luiz Inácio Lula da Silva heeft uitgehaald naar de Verenigde Staten vanwege de oorlog die het land samen met Israël voert tegen Iran. "Waanzin", aldus de Braziliaan, in een toespraak bij de opening van Hannover Messe, een grote handelsbeurs in de Duitse stad.
"We zijn getuige van een cruciaal moment in de wereldwijde geopolitiek, dat gekenmerkt wordt door twee paradoxen: terwijl astronauten naar de maan vliegen, worden vrouwen en kinderen willekeurig gedood bij de bombardementen in het Midden-Oosten", aldus Lula.
Ook noemde Lula het in zijn speech onaanvaardbaar dat in de 21e eeuw honger, ongeletterdheid en een gebrek aan toegang tot elektriciteit nog onopgeloste problemen zijn voor miljarden mensen, terwijl tegelijkertijd 2,7 biljoen dollar wordt uitgegeven aan oorlog.
ROTTERDAM (ANP) - Een container die zondagavond verkeerd is neergezet op een schip op de Maasvlakte bij Rotterdam, lekt een giftige, bijtende stof. Het schip zelf heeft ook schade opgelopen, vertelt een woordvoerster van de veiligheidsregio. "Er is een gat ontstaan in het dek, boven de machinekamer. De stof lekt daar naar binnen", schetst ze de situatie.
Het gaat om een relatief klein lek, dat volgens de hulpdiensten geen gevaar oplevert voor de omgeving. Ook de 22 bemanningsleden van het schip zijn veilig. De woordvoerster weet niet om welke stof het precies gaat, maar het is volgens haar alleen bij aanraking schadelijk.
Hoe het precies misging, is niet geheel duidelijk. De hulpdiensten dachten eerst dat de container uit een kraan was gevallen, maar dat blijkt niet te kloppen. Volgens de woordvoerster is de container gaan schuiven, waarna de problemen ontstonden.
De hulpdiensten werken aan een plan om de container van boord te krijgen of de bijtende stof over te pompen. Dat gaat vermoedelijk nog uren duren.
HOUSTON (ANP) - Een van de wetenschappelijke instrumenten aan boord van de ruimtesonde Voyager 1 is uitgeschakeld. Het apparaat heeft vrijwel onafgebroken metingen verricht sinds de lancering in 1977. Zeven andere meetinstrumenten waren eerder al uitgezet, twee doen het nog. Volgens de Amerikaanse ruimtevaartorganisatie NASA moet de stap energie aan boord sparen en het leven van de verkenner zo lang mogelijk rekken.
Het instrument is de LECP. Die meet geladen deeltjes als ionen, elektronen en kosmische straling. Wetenschappers hebben zo een beter beeld gekregen van de samenstelling van het heelal. Hetzelfde instrument zit ook in een andere sonde, de Voyager 2. Daar is het apparaat vorig jaar uitgeschakeld om energie te besparen.
De Voyager 1 is het verste object dat door mensen is gemaakt. Hij vliegt op ruim 25 miljard kilometer afstand van de aarde. In 2012 verliet hij ons zonnestelsel en bereikte hij de eindeloze ruimte tussen de sterren.
Trump says cargo ship tried to get past US naval blockade near strait of Hormuz ‘and it did not go well for them’
The US military took custody of an Iranian-flagged container ship that attempted to get past an American blockade near the strait of Hormuz, Donald Trump announced on Sunday.
In a social media post, Trump said that an “Iranian-flagged cargo ship named TOUSKA” tried to get past the US naval blockade, “and it did not go well for them”.
Continue reading...Reported response comes hours after Trump announced delegation to Islamabad, having earlier threatened to raze Iran’s infrastructure
Tehran is not currently planning to take part in new talks with the US, Iran state media reported on Sunday evening, hours after Donald Trump said he was dispatching negotiators to Islamabad.
“There are currently no plans to participate in the next round of Iran-US talks,” state broadcaster IRIB said, citing Iranian sources.
Continue reading...Deep lying creator is an excellent Manchester City story and confirmed why he is England’s best left-back
It’s not over, not over, not over yet. Although, let’s be honest, it kind of is over. Isn’t it, don’t you think, at the end of a day when Manchester City and Arsenal dished up the one thing nobody was expecting at the Etihad Stadium, a thrillingly open game of attacking football?
There were three images at the final whistle that seemed to capture the essence of City’s 2-1 win here, and not just in terms of the game, but the balance of energy, feeling, vibes.
Continue reading...
In The Music Video Is Dead, Long Live The Music Video, Patrick (H) Willems explores the history of music videos, how important they were both to culture and to film, and performs a bit of a eulogy to an art form which used to command millions of dollars and today continues is a greatly diminished form. ~1hour
Na de verloren bekerfinale in 2025 tegen Go Ahead Eagles, een trauma voor AZ, waren de Alkmaarders zondag oppermachtig in de finale tegen NEC. „Dit kan niet meer fout gaan”, klonk het na de 3-0.
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