thexiffy

Last.fm last recent tracks from thexiffy.

Elastica - Connection

Elastica

Club Cheval - From The Basement To The Roof

Club Cheval

Bad Religion - American Jesus (Andy Wallace mix)

Bad Religion

Everlast - Babylon Feeling (feat. Carlos Santana)

Everlast

Wel.nl

Minder lezen, Meer weten.

Sporten is goed voor bijna elk deel van je lichaam, laten wetenschappers zien

Spieren doen veel meer dan je laten bewegen of kracht leveren: ze functioneren als een endocrien orgaan dat signalen door het hele lichaam stuurt. Bij elke samentrekking komen honderden stoffen vrij, de zogeheten myokinen, die een cruciale rol spelen in onze gezondheid.

De ontdekking van deze moleculen betekende een kantelpunt in de fysiologie. Het populaire adagium “beweging als medicijn” kreeg wetenschappelijke onderbouwing. Toch is zelfs dat een understatement. Steeds meer onderzoekers stellen dat beweging even essentieel is als eten of ademen en dat een zittende levensstijl eerder als een risicofactor voor ziekte moet worden gezien dan als een neutrale keuze.

Myokinen werken als hormonen en communiceren via de bloedbaan met organen zoals de hersenen, lever en het immuunsysteem. Een van de bekendste is interleukine-6 (IL-6), dat tijdens intensieve inspanning tot honderd keer sterker vrijkomt dan in rust. Andere belangrijke stoffen zijn irisine, dat vetverbranding ondersteunt, en BDNF, een molecuul dat betrokken is bij leervermogen en geheugen.

Aanmaak van afweercellen

De impact van deze signalen is breed. In het immuunsysteem stimuleren myokinen de aanmaak en activiteit van afweercellen en remmen ze chronische ontstekingen, een belangrijke oorzaak van hart- en vaatziekten. In de hersenen activeren ze de zogenoemde spier-brein-as: een communicatielijn die de aanmaak van nieuwe neuronen bevordert en bescherming biedt tegen cognitieve achteruitgang.

Ook op metabolisch vlak zijn spieren bepalend. Tijdens inspanning helpt IL-6 bij het vrijmaken van vetzuren en het reguleren van de bloedsuikerspiegel. Spieren fungeren zo als een soort thermostaat die bepaalt hoe energie wordt opgeslagen of verbruikt. Dit mechanisme verklaart mede waarom regelmatige beweging het risico op diabetes verlaagt.

Daarnaast spelen spieren een rol in de gezondheid van hart en bloedvaten. Door de afgifte van zogeheten exerkinen – stoffen die ook door andere organen worden geproduceerd tijdens beweging – verbeteren bloedvaten hun flexibiliteit en functie. Het resultaat: minder risico op hoge bloeddruk en hartfalen.

Zelfs je botten en de kans op kanker worden beïnvloed door spieractiviteit. Myokinen stimuleren botopbouw en kunnen processen remmen die leiden tot tumorvorming. Onderzoek suggereert dat zelfs één sportsessie al meetbare effecten heeft op moleculen die kankercellen onderdrukken.

Bron: Science Alert


WHO: maatregelen aan boord Hondius tegen verspreiding virus

GENÈVE (ANP) - Op het cruiseschip Hondius zijn voorzorgsmaatregelen getroffen om de kans op verspreiding van het hantavirus zo klein mogelijk te houden. Zo worden de kamers aan boord gedesinfecteerd, blijven opvarenden zoveel mogelijk in hun hut waar ze eten en water krijgen en is gevraagd een mondmasker te dragen. Dat zei de Amerikaanse epidemioloog Maria Van Kerkhove tijdens een persconferentie van de Wereldgezondheidsorganisatie (WHO).

"We adviseren verder mensen die mogelijk besmet zijn meer maatregelen te treffen." Volgens Van Kerkhove gaat het inmiddels beter met de patiënt die op de intensive care ligt in Zuid-Afrika en zijn de twee opvarenden die in Nederlandse ziekenhuizen verblijven stabiel.

Op het cruiseschip zijn momenteel geen andere mensen die symptomen vertonen van het hantavirus.


The Guardian

Latest news, sport, business, comment, analysis and reviews from the Guardian, the world's leading liberal voice

Global race under way to trace passengers who left hantavirus ship before outbreak confirmed

At least 29 passengers of 12 nationalities left the MV Hondius on 24 April after the first fatality

Authorities around the world are racing to trace dozens of passengers who disembarked from the cruise ship at the centre of a deadly hantavirus outbreak before isolation measures were implemented.

It emerged for the first time on Thursday that at least 29 passengers of 12 nationalities left the MV Hondius on 24 April after the first fatality, prompting a scramble to identify and track their movements since then.

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Israeli settler to go on trial over attack on French nun in Jerusalem

Yona Simcha Schreiber from settlement in West Bank faces charge of assault motivated by hostility towards religious group

An Israeli settler suspected of kicking and wounding a French Catholic nun in Jerusalem will go on trial for assault motivated by hostility towards a religious group, Israel’s justice ministry has said.

The attack on the nun, a 48-year-old researcher at Jerusalem’s French School of Biblical and Archaeological Research, occurred on Mount Zion, just outside the Old City.

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Spain awards UN legal expert Francesca Albanese one of its highest civilian honours

Honour recognises Albanese’s work ‘documenting and denouncing violations of international law in Gaza’

The Spanish government awarded the UN legal expert Francesca Albanese one of its highest civilian honours in recognition of what it termed her “extensive work in documenting and denouncing violations of international law in Gaza”.

Albanese, an Italian human rights lawyer who serves as the UN special rapporteur on the situation of human rights in the Palestinian territories occupied since 1967, has been vocal in her criticisms of Israel’s military operations in Gaza, which she has described as genocide.

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Champions League review: a punch for Arteta and are PSG and Arsenal really that different?

The teams for the final in Budapest are set. We look at how they got there and the factors that could determine the champion

Destination Budapest, where Paris Saint-Germain will attempt to be the first club apart from Real Madrid to win two consecutive European Cups since Milan in 1990. Vincent Kompany’s promise of “more” from Bayern Munich after a nine-goal first leg did not materialise. PSG offered a different proposition in Wednesday’s second leg; they put on a performance of defensive discipline, with their attacking players committed to closing down their opponents. Luis Enrique’s team never allowed the tie to spin from their control even if there were 33 shots in Munich compared to 22 in Paris.

Khvicha Kvaratskhelia plays like an old-style winger, and set up Ousmane Dembélé’s goal, but he is also thoroughly modern in the way he presses hard and high. Bayern found space at a premium until Harry Kane’s late goal. Luis Enrique’s team is much the same as last season’s, sticking to the same formula. They are a year older but still flush with youth. The PSG project took many years and billions of euros to hit pay dirt but is now delivering the success that was dreamed of after the Qatari takeover in 2011.

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Jonas Vingegaard targets Grand Tour slam as Giro d’Italia begins in Bulgaria

Double Tour de France winner makes his debut when race begins on Friday and is the outstanding favourite for victory in Rome

Jonas Vingegaard’s bid to complete a rare Grand Tour grand slam by winning the 2026 Giro d’Italia begins in Bulgaria on Friday when the double Tour de France winner makes his debut in the Italian race.

Vingegaard, the winner of the 2022 and 2023 Tours de France, has been eclipsed by the achievements of Tadej Pogacar – winner this season of nine races in 11 days of racing – but is the outstanding favourite for victory in Rome on 31 May.

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The Pretender by Jo Harkin audiobook review – sprightly historical political skulduggery

This 15th-century royal romp of intrigue and courtly conspiracy is given extra charismatic verve by John Hollingworth’s rambunctious narration

It is 1483 and 10-year-old John Collan is living on a farm outside Oxford with his father, Will, and waging war on an aggressive goat that keeps trampling him. His mother is long dead and his older twin brothers, Oliver and Tom, have left home to begin apprenticeships. One morning John overhears the dairy maid Jennot discussing how Edward Plantagenet and his younger brother Richard, sons of the late King Edward IV, have been imprisoned in the Tower of London by their uncle Richard, Duke of Gloucester. Later, a well-dressed man arrives on a chestnut horse for a meeting with his father. John learns that the man is his benefactor who has paid for him to be tutored. “A bright future!” Will tells his son. “But secret for now.”

A dramatic imagining of the true story of the royal impostor Lambert Simnel, Jo Harkin’s novel tells of a farmboy who is told that he is Edward V, 17th Earl of Warwick, rightful heir to the English throne and the elder prince in the tower. Having been tutored in great literature and courtly ways, our protagonist becomes a hapless pawn in the games of ambitious conspirators and is sent to Ireland where he becomes the figurehead of the Yorkist rebellion against the so-called usurper Henry VII.

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Flutes, freestyles and infectious fun: Lizzo’s greatest songs – ranked!

Ahead of her new album, Bitch, we rate the best of a singer who expertly suffuses self-empowerment anthems with humour and party-starting energy

Lizzo’s contribution to the Barbie soundtrack fitted the film’s opening scene perfectly: fluffy, wilfully lightweight disco-pop, with lyrics that split the difference between being knowingly daft and offering a self-empowerment message. If you’re not in the market for high-camp positivity, try the Pink (Bad Day) version, which flips the track’s mood on its head.

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Geen peuken meer tussen de planten in het eerste rookvrije park in Breda (hoewel paffen niet écht wordt verboden)

In Breda werd woensdag het eerste rookvrije park van Nederland geopend. Hoewel handhaving uitblijft, vinden ouders het prettig voor hun kinderen. „Zo houden we de kids zo veel mogelijk uit de rook.”


Voor PSV-vrouwen lonkt de allereerste landstitel. Er is acht jaar naartoe gewerkt

Voor de derde maal staan de vrouwen van PSV op het punt om landskampioen te worden. Tweemaal ging het nét mis. Achter de schermen werkt manager vrouwenvoetbal Sandra Doreleijers al sinds 2018 aan dat doel.


kottke.org

Jason Kottke's weblog, home of fine hypertext products

Animated Artemis II Photos Reveal Satellites Buzzing Around Earth

Ok, this is incredible: this person on Reddit discovered that if you take a bunch of the sequential photos of the Earth captured by the Artemis II crew and animate them, you can see that some of what appear to be stars are actually satellites, buzzing around the Earth like flies. You can see them really clearly in Seán Doran’s remastered animation. Totally totally gobsmacking. Literally awesome.

Tags: artemis · astronomy · Earth · photography · science · Sean Doran · space

“Podcast sloplords” are flooding the zone...

“Podcast sloplords” are flooding the zone with AI-generated podcasts. By one count, almost 40% of new podcasts are written by AI chatbots and presented by “AI voice synthesizers [that] can sound eerily humanlike”.

VK: Voorpagina

Volkskrant.nl biedt het laatste nieuws, opinie en achtergronden

Nee, dan de krentenwegers van de Wegenwacht

The Register

Biting the hand that feeds IT — Enterprise Technology News and Analysis

C++ survey finds AI use rising, though trust is in short supply

The Standard C++ Foundation's annual developer survey shows AI use among C++ programmers is rising fast, though mistrust and resistance remain stubbornly high. The poll, billed as a “10-minute survey to help inform C++ standardization and C++ tool vendors,” drew 1,434 respondents, 38 percent more than last year. It likely reflects the views of developers most engaged with C++ and its evolution, rather than the wider C++ community. That supposition is confirmed by a question on what type of projects respondents work on, with more than 26 percent saying they work on developer tools such as compilers and code editors – higher than one would expect. 60.5 percent of respondents say they have more than 10 years' experience developing with C++, and 32.7 percent more than 20 years, so this is a mature crowd. A key point of interest is what has changed since last year, with AI the most notable example. 39.8 percent of respondents use AI for writing code frequently, versus 30.9 percent last year. There is also more use of AI for other tasks such as writing tests (up from 20 to 33 percent) and for debugging (up from 11.5 to 23.6 percent). That said, there is also notable resistance to AI. 42 percent (down from 52.7 percent last year) rarely or never use AI for coding or other tasks. Issues with AI (among both adopters and non-adopters) include incorrect output, lack of trust in the output, data privacy concerns, and the cost of AI tools. Several of the survey questions invite write-in responses, which to our annoyance are not published but sent only to members of the standards committee and product vendors. An AI-generated summary is published instead. Issues with AI, according to this summary, include struggles with large projects and complex build systems. Some write-ins had stronger language, including claims that AI is "burning the planet." When asked what developers would like to change about C++, the themes, again according to a summary, are similar to those mentioned last year, including the lack of a standard package manager; the complexity of managing headers, includes, and macros; long build times; bugs from undefined behavior and implicit conversions; lack of memory safety; obscure error messages from tools; and gaps in the standard library forcing use of third-party libraries. Respondents valued the ISO/WG21 C++ standards committee as essential and transparent, but it also came under fire for slow progress and over-complex language design – perhaps with some contradiction since respondents want it both to do more and to do less. C++ remains among the most popular programming languages. A recent language survey from RedMonk ranks it in seventh place, or sixth if you do not count CSS (Cascading Style Sheets), behind JavaScript, Python, Java, C#, and TypeScript. Rust, often put forward as a safer alternative, lies in 20th place. Last year, SlashData claimed that C++ has "grown from 9.4 million developers in 2022 to 16.3 million in 2025," a figure quoted by former standards committee chair Herb Sutter, who said that C++, C, and Rust are growing because of their hardware efficiency, "performance per watt." At the same time, there is widespread dissatisfaction with C++, shown not only by the comments in surveys like this one, but by projects like Google's Carbon, a proposed "successor language" whose README refers to the "accumulating decades of technical debt" in C++ and claims that "incrementally improving C++ is extremely difficult, both due to the technical debt itself and challenges with its evolution process." The Carbon team hopes to ship a "working 0.1 language for evaluation" by the end of 2026 at the earliest; it will be controversial and a long way from production-ready. In the meantime, C++ usage shows no sign of decline despite the fact that many developers will readily reel off a list of its faults and problems. ®

Kassa. Koninklijke familie Verenigde Arabische Emiraten vangt 71 miljoen landbouwsubsidie EU

FOTO - United Arab Emirates (UAE) Deputy Prime Minister and Minister of Foreign Affairs Sheikh Abdullah bin Zayed Al Nahyan (R) meets with the European Union's High Representative for Foreign Affairs and Security Policy Kaja Kallas to discuss bilateral ties and regional developments, in Abu Dhabi, United Arab Emirates, on April 9, 2026.

Mooi nieuws voor iedereen die zich afvraagt of de EU nog iets nuttigs gaat doen met de 2,2 biljoen euro die ze de komende zes jaar uit wil geven: het geld verdwijnt niet allemaal in een put. Sommige landbouwsubsidies komen namelijk terecht bij mensen die het écht goed kunnen gebruiken, zoals de familie Al Nahyan uit de Verenigde Arabische Emiraten. Dat is de machtigste koninklijke familie van de VAE, met een geschat vermogen van 270 miljard euro. Zij ontvingen, via dochterbedrijven, maar liefst 71 miljoen euro aan landbouwsubsidie volgens de Birtse Grauniad, voor hun boerderijen in Roemenië, Italië en Spanje. Je moet er toch niet aan denken dat er iets anders met dat geld zou zijn gebeurd, bijvoorbeeld dat het in de zakken van de Europese Nederlandse belastingbetaler zou blijven zitten. Dan zouden die er alleen maar vapes van kopen of boeken van Sarah J. Maas of andere onzin. Was het maar alvast Europadag, dan konden we de EU hier lekker voor bedanken.