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The Guardian view on cancer treatments: new hope for patients now and in the future | Editorial

A drug for pancreatic cancer shows immense promise, but we shouldn’t forget research in the field is a story of small victories

It is unlikely that we will ever declare a final victory over cancer. Governments have often promised it: from Nixon’s 1971 “war on cancer” to the 2016 Obama‑Biden plan to fight and cure it “once and for all” and Sajid Javid’s 2022 “war on cancer” initiative in the UK. But framing it this way can obscure how real progress is made: not in stunning routs, but in stalling and turning back the advance of this terrible condition – often in simply giving people more time to live.

Several such breakthroughs, and a bigger one that could transform the treatment of multiple kinds of cancer over the next decade, emerged at last week’s American Society of Clinical Oncology meeting in Chicago. As the Guardian revealed, there is a new jab effective against head and neck cancers in some patients, and a new immunotherapy that could spare bladder cancer patients invasive and life-changing surgery. Most significantly, there is a new drug called daraxonrasib, which doubled survival time for pancreatic cancer patients in a recent clinical trial.

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Kimi Antonelli holds nerve to win chaotic F1 Monaco GP after late red flag

  • Italian teenager becomes youngest winner of race

  • Lewis Hamilton second but Russell pays penalty

Kimi Antonelli won the Monaco Grand Prix for Mercedes with a dominant drive from pole to flag, becoming at 19 the youngest victor on the streets of Monte Carlo, in only his second F1 race at the circuit. In a dramatic close to the race he held his nerve through two restarts under immense pressure.

The Italian delivered a consummate exhibition to take victory from Lewis Hamilton in second and the Red Bull of Isack Hadjar in third, though neither really challenged the Mercedes. However, Antonelli had to weather nervelessly the tense final moments of a safety-car restart and then a full standing start after a red flag because the track itself was breaking up at the final corner.

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How do I know when I’ve hit perimenopause?

Doctors say diagnosis is usually clinical and doesn’t rely on a blood test, with symptoms often starting in the mid-40s

There’s a special frisson to period changes in your mid-forties. Every deviation from your usual pattern can feel like a harbinger of the menopause transition, also known as perimenopause.

One might spend years staring at their underwear, wondering: am I or aren’t I?

Keren Landman MD is an independent health reporter who is also trained as an infectious disease physician and epidemiologist, with experience serving as a disease detective at the CDC and conducting HIV and malaria research in resource-poor countries. Her public health newsletter is called Landmansplained

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Niet Van der Breggen, maar Vollering wint de Giro na spectaculaire slotetappe

Dat een Nederlandse renster de Giro d’Italia ging winnen, was aan het begin van dit weekend wel duidelijk. Maar dat Demi Vollering in de slotetappe alsnog koploper Anna van der Breggen wist te kraken (met dank aan een Duitse concurrente), was toch een grote verrassing.

Rijnmond - Nieuws

Het laatste nieuws van vandaag over Rotterdam, Feyenoord, het verkeer en het weer in de regio Rijnmond

Iedereen kan zijn grootste hit meezingen, toch verdween deze Rotterdamse artiest uit de schijnwerpers

'Het is altijd lente in de ogen van de tandartsassistente' is een iconische liedtekst, die iedereen kan meezingen. Toch kennen maar weinig mensen de artiest die het nummer uitbracht. Rotterdammer Peter de Koning (66) scoorde eind jaren '90 een megahit, maar verdween daarna bewust uit de schijnwerpers.

Niku (肉)

guineapig33 has added a photo to the pool:

Niku (肉)

Camera: Minolta X-700 with MD 35-70mm f/3.5 lens
Film: Handsonfilm Midnight 1600
Developed & Scanned by @handsonfilm

Although the Japanese and Chinese languages are two distinct languages, they do still have some interesting similarities. One will note that both languages will make use of Chinese characters in their writing systems, although how it is actually used differs, of course.

For speakers of both languages, this can sometimes make it easier to make a rough guess of what it might mean, such as the character for meat, Niku (肉), shown in the photo here. One would likely infer that this would be a restaurant serving meat.

Minor auto adjustments in Adobe Lightroom were made only when necessary in order to preserve the original film roll colours.

VK: Voorpagina

Volkskrant.nl biedt het laatste nieuws, opinie en achtergronden

Het fijne nieuwe Nederlandse bandje Pom klinkt live lekker vuig en dat levert precies de goede energie op

Wel.nl

Minder lezen, Meer weten.

Spaanse golfer Chacarra schrijft KLM Open op zijn naam

BADHOEVEDORP (ANP) - Golfer Eugenio Chacarra heeft het KLM Open in Badhoevedorp op zijn naam geschreven. De 26-jarige Spanjaard eindigde met één slag voorsprong op de Fin Oliver Lindell. Golfer Lars van der Vight werd de beste Nederlander op de 38e plaats.

Chacarra deelde na drie ronden nog de leiding met de Zweed Sebastian Söderberg op -10. De Spanjaard eindigde zondag op -11 na een birdie op de laatste hole. Hij sloeg daarmee een late aanval van Lindell (-10) af. Söderberg werd gedeeld derde op -8. Het is voor Chacarra de tweede zege op de DP World Tour, oftewel de Europese Tour.

Van der Vight tekende op de laatste dag voor een score van 76 slagen (5 boven het baangemiddelde) en eindigde op een totaal van +1. Hij wist op de slotdag geen enkele birdie te maken. Toch hield hij Joost Luiten en de amateur Nevill Ruiter, de enige andere Nederlanders die de 'cut' haalden, ruimschoots achter zich.

Luiten, die zaterdag na een slechte ronde voor commotie zorgde door te zeggen dat hij overwoog om zijn caddie te vervangen, ging een dag later rond in 74 slagen (+3). Hij eindigde met een totaal van +6 op de zestigste plaats. Ruiter, de enige amateur in het weekend, leverde een kaart in van 78 slagen (+7). Hij besloot het toernooi als 66e.


Feyenoord gestopt met Robin van Persie

Van alle domme ideeën is het waanbeeld dat een goede voetballer vanzelfsprekend ook een goede trainer is een van de hardnekkigste. Zie bijvoorbeeld: Marco van Basten, Dirk Kuyt, John Heitinga, Danny Blind, Ruud Gullit, Jaap Stam, Ruud van Nistelrooij. Omdat bij voetbalclubs vaak volidioten werken die ook maar wat doen, blijft de geschiedenis zich herhalen. Omdat bij Feyenoord op 1 juli twee directeuren (Dévy Rigaux en Robert Eenhoorn) beginnen die geen volidioten zijn, mag Van Persie vast zijn biezen pakken. Dat is: sneu voor hem, maar ook volkomen terecht, en leuk voor alle supporters van de club. Gefeliciteerd ermee, jongens.

Andreas Gohr: Weblog [splitbrain.org]

Weblog on technology, programming and personal stuff by Andreas Gohr.

Pallet Wood Crafting Table

Pallet Wood Crafting Table

One of my favorite YouTube channels is EpicUpCycling. If you don't know it, check it out. Jason builds amazing things out of pallet wood.

I'm far from his skill, but he taught me not to throw away or just burn pallets. The wood might look shabby but with a bit of work you can make it into something beautiful.

As fate would have it, Kaddi wanted a dedicated crafting table in the office and at the same time I had some pallets from recent deliveries - so why not give it a go and make a table from them.

Processing pallets doesn't take much skill, just time. The hardest part is to take them apart and remove the nails without breaking the wood. From there on the process is:

  1. send each board through the thickness planer until all boards are somewhat clean and have the same thickness
  2. straighten the edges, ideally using a jointer, but I find the table saw to be good enough
  3. glue the boards into panels using lots of clamps
  4. fill in all the holes and imperfections with dowels and/or wood filler
  5. sand everything. first with the belt sander at 80 grit and then with the orbital sander up to 240 grit

Of course, each of these steps takes longer than you think. At least longer than a YouTube montage makes you think it would. But I find it really meditative. It's a great way to relax after a full day of mental work. Just do something with your hands, listen to a podcast and push boards through the planer…

For the crafting table, I started with the table top. To make it look beefier than it is and give it a little more stability, I framed the two visible edges with a 2×1 which I routed into an L-shape and joined with a miter.

Part of the top reaches over the heating radiator, so I added a ventilation grate. The grate itself is 3D printed, using a hexagon pattern matching the theme of our office and because hexagons are bestagons.

The table top is held up by two side panels connected by a large shelf. I will probably create custom inserts for the shelf at a later point. Maybe some drawers, maybe some larger containers.

Of course I had to fuck up somewhere and my measurements were off – the whole shelf was like 5cm too wide. I had to cut it and glue it up again. That was annoying.

For finish, I decided to keep the desktop's pallet origins visible and just oil it – that also matches our main plain wood desks. The sides and shelf are painted with the same chalk paint we painted our printer cupboard with.

So far, I am happy with the build. The thing I'm most worried about, is warping. We'll see how it goes. If it all goes wrong, I might try to route some channels in the top's underside and embed some steel bands as I have seen on commercial tables.

Tags:
woodworking, carpentry, diy, furniture
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